Toxins and antitoxins
نویسندگان
چکیده
منابع مشابه
Toxins and Antitoxins of Bacillus Dysenteriæ Shiga
With the methods which have been described we have separated an exotoxin and an endotoxin from cultures of the Shiga dysenteric bacillus. The study of the nature and effect of the poison of this microorganism is thus simplified. The two toxins are physically and biologically distinct. The exotoxin is relatively heat-labile, arises in the early period of growth, and yields an antiexotoxic immune...
متن کاملOne cannot rule them all: Are bacterial toxins-antitoxins druggable?
Type II (proteic) toxin-antitoxin (TA) operons are widely spread in bacteria and archaea. They are organized as operons in which, usually, the antitoxin gene precedes the cognate toxin gene. The antitoxin generally acts as a transcriptional self-repressor, whereas the toxin acts as a co-repressor, both proteins constituting a harmless complex. When bacteria encounter a stressful environment, TA...
متن کاملProduction of antitoxins to two toxins of Clostridium difficile and immunological comparison of the toxins by cross-neutralization studies.
We prepared antitoxins specific for each of two toxins of Clostridium difficile and used these to demonstrate that the toxins are immunologically distinct.
متن کاملThe Dose of Antitoxins
? columns the tendency to draw far reaching conclusions on inadequate grounds purporting to be based on experimental data, I take the opportunity offered by Major Carr-Whiteis interesting paper " Is Antivenene of any value in Cobra Poisoning, in your current number to again draw attention to this important matter in relation to the anti-toxins, taking for illustration anti-venene, anti-tet ino-...
متن کاملVapC Toxins from Mycobacterium tuberculosis Are Ribonucleases that Differentially Inhibit Growth and Are Neutralized by Cognate VapB Antitoxins
The chromosome of Mycobacterium tuberculosis (Mtb) encodes forty seven toxin-antitoxin modules belonging to the VapBC family. The role of these modules in the physiology of Mtb and the function(s) served by their expansion are unknown. We investigated ten vapBC modules from Mtb and the single vapBC from M. smegmatis. Of the Mtb vapCs assessed, only Rv0549c, Rv0595c, Rv2549c and Rv2829c were tox...
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ژورنال
عنوان ژورنال: The Dublin Journal of Medical Science
سال: 1900
ISSN: 0790-231X
DOI: 10.1007/bf02972883